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Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1
(Wiley-liss, Div John Wiley & Sons Inc, 2015-12)
We have previously demonstrated a crucial role of nuclear protein 1 (NUPR1) in tumor development and progression. In this work, we report the functional characterization of a novel Nupr1-like isoform (NUPR1L) and its ...
The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
(Public Library of Science, 2019)
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation
(Nature Publishing Group, 2015-11)
Nupr1 is a chromatin protein, which cooperates with Kras(G12D) to induce PanIN formation and pancreatic cancer development in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. ...
Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma
(Elsevier Ireland, 2020-08)
HCC is a highly lethal malignancy with Sorafenib as the only molecularly targeted drug. The multifunctional stress-associated protein, NUPR1, plays an essential role in controlling cell growth, migration, invasion and ...
The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
(Public Library of Science, 2019)
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage
(Wiley, 2009-12)
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby ...
Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: an exploratory study
(Springer, 2017-11)
Neoadjuvant (or induction) chemotherapy can be used for cervical cancer patients with locally advanced disease; this treatment is followed by radical surgery and/or radiation therapy. Cisplatin is considered to be the most ...
Estudio del potencial antiproliferativo de extractos obtenidos de residuos frutícolas desde las perspectivas de la química verde y la alimentómica
(Bogotá - Ciencias - Doctorado en Ciencias - QuímicaDepartamento de QuímicaUniversidad Nacional de Colombia - Sede Bogotá, 2020-05-28)
En este trabajo se presenta una estrategia multianalítica para la valorización de subproductos de frutas, entre los que se incluyen la almendra de la semilla de mango (Mangifera indica L.), el cáliz de uchuva (Physalis ...