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Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor
(American Chemical Society, 2007)
In the absence of hormone, corticosteroid receptors are primarily located in the cytoplasm, and they rapidly accumulate in the nucleus (t0.5 = 5 min) upon ligand binding. It is generally believed that the dissociation of ...
Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer
(Nature Publishing Group, 2007)
The role of oxidative stress in prostate cancer has been increasingly recognised. Acute and chronic inflammations generate reactive oxygen species that result in damage to cellular structures. Haeme oxygenase-1 (HO-1) has ...
Identification of a putative nuclear localization signal in the tumor suppressor maspin sheds light on its nuclear import regulation
(2019-07-01)
The tumor suppressor activity of maspin (mammary serine protease inhibitor) has been associated with its nuclear localization. In this study we explore the regulation of maspin nuclear translocation. An in vitro nuclear ...
Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes
(Endocrine Society, 2006-11-11)
The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release ...
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
(2018)
The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include activation of Ca2+ ...
Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of pregnanesteroids
(Elsevier Ireland, 2003-12)
The mineralocorticoid receptor (MR) is primarily localized in the cytoplasm of the cell in the absence of ligand. The first step in the genomic-dependent mechanism of action of mineralocorticoids is the binding of steroid ...
Carbon translocation from a plant to an insect-pathogenic endophytic fungus
(Nature Communications, 2018)