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Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Universidade Estadual Paulista (Unesp) (Instituto Oswaldo Cruz, Ministério da Saúde, 2013-02-01)

The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months. ...

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Universidade Estadual Paulista (Unesp) (Instituto Oswaldo Cruz, Ministério da Saúde, 2013-02-01)

Mutations in hepatitis C virus NS3 protease domain associated with resistance to specific protease inhibitors in antiviral therapy naïve patients

Silva, Allan Peres da; Almeida, Adilson José de; Lampe, Elisabeth (Springer Verlag, 2017)

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Zeminian, Luciana Bonome; Padovani, Juliana Lara; Corvino, Sílvia Maria; Silva, Giovanni Faria; Pardini, Maria Ines de Moura Campos; Grotto, Rejane Maria Tommasini (Instituto Oswaldo Cruz, Ministério da Saúde, 2014)

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

Dultz, Georg; Shimakami, Tetsuro; Schneider, Markus; Murai, Kazuhisa; Yamane, Daisuke; Marion, Antoine; Zeitler, Tobias M.; Stross, Claudia; Grimm, Christian; Richter, Rebecca M.; Bäumer, Katrin; Yi, MinKyung; Biondi, Ricardo Miguel; Zeuzem, Stefan; Tampé, Robert; Antes, Iris; Lange, Christian M.; Welsch, Christoph (American Society for Biochemistry and Molecular Biology, 2020-10)

Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these ...

Análise energética das interações intermoleculares dos inibidores dipeptídicos CN-716 E ACIL-KR-ALDEÍDO com a protease de replicação viral NS2B-NS3 do zika vírus

Campos, Daniel Melo de Oliveira (BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS, 2020-03-17)

The emergent Zika virus (ZIKV) infection has become a threat to global health due to the association with severe neurological abnormalities, namely Guillain-Barre Syndrome (GBS) in adults and Congenital Zika virus Syndrome ...

The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank

Alves, Rafael; Queiroz, Artur Trancoso Lopo de; Pessoa, Mario Guimarães; Silva, E. F. da; Mazo, Daniel Ferraz de Campos; Carrilho, Flair José; Carvalho-Filho, R. J; Carvalho, Isabel Maria Vicente Guedes de (John Wiley & Sons Ltd, 2014)

Genetic diversity of NS3 protease from Brazilian HCV isolates and possible implications for therapy with direct-acting antiviral drugs

Silva, Allan Peres da; Almeida, Adilson José de; Lampe, Elisabeth (Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2017)

In-depth phylogenetic analysis of hepatitis C virus subtype 1a and occurrence of 80K and associated polymorphisms in the NS3 protease

Santos, André F.; Bello, Gonzalo; Vidal, Luãnna L.; Souza, Suiane L.; Mir, Daiana; Soares, Marcelo A. (Nature Publishing Group, 2017)

Protease inhibitor resistance mutations in untreated Brazilian patients infected with HCV: Novel insights about targeted genotyping approaches.

Carvalho, Isabel Maria Vicente Guedes de; Silva, Rafael Alves da; Souza, Polyana A Vasconcelos Medeiros de; Silva, Edvaldo F. da; Mazo, Daniel Ferraz de Campos; Carrilho, Flair José; Queiroz, Artur Trancoso Lopo de; Pessoa, Mario Guimarães (Wiley Periodicals, Inc, 2014)

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Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Mutations in hepatitis C virus NS3 protease domain associated with resistance to specific protease inhibitors in antiviral therapy naïve patients

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

Análise energética das interações intermoleculares dos inibidores dipeptídicos CN-716 E ACIL-KR-ALDEÍDO com a protease de replicação viral NS2B-NS3 do zika vírus

The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank

Genetic diversity of NS3 protease from Brazilian HCV isolates and possible implications for therapy with direct-acting antiviral drugs

In-depth phylogenetic analysis of hepatitis C virus subtype 1a and occurrence of 80K and associated polymorphisms in the NS3 protease

Protease inhibitor resistance mutations in untreated Brazilian patients infected with HCV: Novel insights about targeted genotyping approaches.