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NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis
(WILEY, 2006)
The liver plays a critical role in the metabolism of lipoprotein cholesterol and in controlling its elimination through the bile. Niemann-Pick type C 2 (NPC2), a cholesterol-binding protein, is key for normal intracellular ...
NPC1 as a Modulator of Disease Severity and Viral Entry of SARS-CoV-2
(2020)
The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1,
MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal ...
Estudio farmacogenético en Saccharomyces cerevisae : identificación de genes moduladores de la respuesta a Rapamicina en la enfermedad de Niemann Pick tipo C
(Universidad de Chile, 2023)
La enfermedad de Niemann Pick tipo C (NPC) es un trastorno de almacenamiento lisosomal causado por mutaciones de pérdida de función en los genes NPC1 y NPC2, que codifican proteínas lisosomales transportadoras de colesterol. ...
Efeitos da expressão do gene RPMS1 do vírus de Epstein-Barr em células humanas cultivadas in vitro
(Universidade Estadual Paulista (Unesp), 2020-11-26)
O vírus Epstein-Barr (EBV) - formalmente gammaherpesvirus humano 4 (HHV-4) - é um herpesvírus associado ao desenvolvimento de uma variedade de malignidades humanas. Entre elas, destacam-se o linfoma de Burkitt (BL) e o ...
Viral Carcinogenesis Beyond Malignant Transformation: EBV in the Progression of Human Cancers
(2016-08-01)
Cancer progression begins when malignant cells colonize adjacent sites, and it is characterized by increasing tumor heterogeneity, invasion and dissemination of cancer cells. Clinically, progression is the most relevant ...
Human Placental Intracellular Cholesterol Transport : A Focus on Lysosomal and Mitochondrial Dysfunction and Oxidative Stress
(2022-03)
The placenta participates in cholesterol biosynthesis and metabolism and regulates ex-change between the maternal and fetal compartments. The fetus has high cholesterol requirements, and it is taken up and synthesized at ...
Efeitos dos miRNAs humanos miR-100-5p, miR-192-5p e miR-574-3p na expressão gênica e migração em célula imortalizada de nasofaringe
(Universidade Estadual Paulista (Unesp), 2022-02-21)
Os cânceres são doenças neoplásicas malignas com etiopatogenia complexa. As células transformadas adquirem diversas propriedades que propiciam alterações em taxas de migração, invasão e sobrevivência celular, facilitando ...
Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricularzone-derived neural progenitor cell neurospheres
(Public Library of Science, 2015-04)
Neural Stem and Progenitor Cells (NSC/NPC) are gathering tangible recognition for their uses in cell therapy and cell replacement therapies for human disease, as well as a model system to continue research on overall neural ...
The impact of intensification process on environmental and productive parameters during growing and finishing phase of beef cattle raised in palisadegrass grazing system
(Universidade Estadual Paulista (Unesp), 2021-05-12)
Devido à preocupação decorrente dos impactos ambientais causados pela pecuária de corte, este estudo objetivou identificar o impacto ambiental e produtivo do processo de intensificação da produção pecuária, a fim de ...