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Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia
(2021-04-01)
This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-κB pathway in monocytes from pregnant women with preeclampsia (PE). Monocytes from 20 ...
Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia
(2019-04-19)
Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women ...
Revealing the Salmo salar NLRP3 Inflammasome: Insights from Structural Modeling and Transcriptome Analysis
(MDPI, 2023)
The NLRP3, one of the most heavily studied inflammasome-related proteins in mammals, remains inadequately characterized in Atlantic salmon (Salmo salar), despite the significant commercial importance of this salmonid. The ...
Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus
(INFORMA HEALTHCARELONDON, 2012)
Recent findings provide evidence of inflammasome critical role in the predisposition to autoimmune disorders. The involvement of inflammasome in the pathogenesis of systemic lupus erythematosus (SLE) has been hypothesized ...
Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
(Wiley, 2018)
The study of the mechanisms that trigger inflammation in adipose tissue is key to understanding and preventing the cardiometabolic consequences of obesity. We have proposed a model where activation of the G protein-coupled ...
Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide
(2022-01-01)
This study aimed to evaluate the immunomodulatory effect of vitamin D (VD) on the NLRP1 and NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women. Placental explants from ...
NLRP3 inflammasome: A therapeutic option for kidney disease?
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Pública, 2017-01-01)
Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with ...
Contribution of inflammasome genetics in Plasmodium vivax malaria.
(Elsevier B.V., 2016)
The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection
(Springer, 2017-02)
The innate immune system is essential for the detection and elimination of Bacterial pathogens. Upon inflammasome activation, caspase-1 cleaves pro-IL-1β and pro-IL-18 to their mature forms IL-1β and IL-18, respectively, ...