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Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia
(2021-04-01)
This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-κB pathway in monocytes from pregnant women with preeclampsia (PE). Monocytes from 20 ...
Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia
(2019-04-19)
Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women ...
Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide
(2022-01-01)
This study aimed to evaluate the immunomodulatory effect of vitamin D (VD) on the NLRP1 and NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women. Placental explants from ...
Papel do inflamassoma NLRP3 em modelo de infecção sistêmica por Sporothrix schenckii
(Universidade Estadual Paulista (Unesp), 2016-12-09)
A esporotricose é uma infecção fúngica causada pelas espécies do complexo Sporothrix, incluindo Sporothrix schenckii sensu stricto. Os receptores de reconhecimento padrão (PRRs), pertencentes às células da resposta imune ...
Endogenous and uric acid-induced activation of NLRP3 inflammasome in pregnant women with preeclampsia
(Public Library Science, 2015-06-08)
Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and proteinuria. This pathology is associated with hyperuricemia and elevated serum levels of inflammatory cytokines. Uric acid crystals ...
Nlrp3 activation and its relationship to endothelial dysfunction and oxidative stress: Implications for preeclampsia and pharmacological interventions
(2021-11-01)
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating ...
Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
(Wiley, 2018)
The study of the mechanisms that trigger inflammation in adipose tissue is key to understanding and preventing the cardiometabolic consequences of obesity. We have proposed a model where activation of the G protein-coupled ...
NLRP1 L155H polymorphism is a risk factor for preeclampsia development
(Wiley-Blackwell, 2015-06-01)
Problem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. ...
NLRP3 inflammasome: A therapeutic option for kidney disease?
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Pública, 2017-01-01)
Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with ...