The hydroxamic acids (RC(O)NHOH, HA) exhibit diverse biological activity, including hypotensive properties associated with formation of nitroxyl (HNO) or nitric oxide (NO). Oxidation of two HAs, benzohydroxamic and ...

The present review starts describing nitroxyl (azanone, 1HNO) biological relevance, in relation with NO physiology, from a chemical reactivity perspective. After a description of commonly used azanone donors and their ...

Hypertension is a disorder affecting millions worldwide, and is a leading cause of death and debilitation in the United States. It is widely accepted that during hypertension and other cardiovascular diseases the vasculature ...

We present a new method for controlled generation of HNO, based on the combination of a pH photoactuator induced by visible light with an HNO donor activated by pH increase. This method avoids the use of UV light, and in ...

Nitroxyl (HNO) is a highly elusive and reactive molecule. Nitroxyl biological effects and pharmacological potential are becoming increasingly relevant. Mycobacterium tuberculosis infection needs new and more efficient ...

Glutamate is the main excitatory neurotransmitter in the retina, but it is toxic when present in excessive amounts. It is well known that NO is involved in glutamate excitotoxicity, but information regarding the possibility ...

Stomatal pore regulation is a key process for carbon and water homeostasis of terrestrial plants. The pore size is modulated through changes in the guard cell volume, driven by variations in the osmotic potential of the ...

The circadian clock at the hypothalamic suprachiasmatic nucleus (SCN) entrains output rhythms to 24-h light cycles. To entrain by phase-advances, light signaling at the end of subjective night (circadian time 18, CT18) ...