The electrochemical nitroreduction of nitrofurantoin has been studied on carbon paste and glassy carbon electrodes. We can observe a monoelectronic reversible couple ArNO2/ArNO2- and an irreversible peak due to the further ...

Tuberculosis (TB) is an infectious disease caused predominantly by Mycobacterium tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in 2019. The lack of new drugs to treat drug-resistant ...

In this work, a series of lactone 1,4-dihydroquinoline derivatives 4 were efficiently synthesized and characterized by 1H and 13C NMR. The synthesized compounds were evaluated for their in vitro antibacterial activity ...

It is important to determine the toxicity of compounds and co-solvents that are used in cell monolayer permeability studies to increase confidence in the results obtained from these in vitro experiments. This study was ...

A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC(50) values lower than standard drugs. Brief SAR analysis revealed ...

2,1-Benzisoxazoles have been selectively synthesized through reductive heterocyclization of 2-nitroacylarenes using Pt-supported nanoparticles. The reaction involves a cascade process in which the first step is the reduction ...

Kinetic and product studies indicate that the title compound decomposes in aqueous solutions to give 5-nitro-2-aminophenol with the intermediacy of N-(2-hydroxy-4-nitrophenyl)carbamic acid. © 1991.

Several nitrofurans and nitroimidazoles have been widely used in veterinary medicine. Some of these compounds are breast carcinogens in rodents and their mechanism of action is hypothesized to be related to reactive ...

In a recent study the cytotoxic activity of a series of nitro aromatic compounds were evaluated against cancer cell lines in vitro. The amides N-[4(chloromethyl)-3-nitrobenzoyl]morpholine and 4-(chloromethyl)-3-nitro-Npr ...