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The regulation of NHE₁ and NHE₃ activity by angiotensin II is mediated by the activation of the angiotensin II type I receptor/phospholipase C/calcium/calmodulin pathway in distal nephron cells
(Amsterdam, 2013-12-05)
Angiotensin II (Ang II), acting via the AT1 receptor, induces an increase in intracellular calcium [Ca(2+)]i that then interacts with calmodulin (CaM). The Ca(2+)/CaM complex directly or indirectly activates sodium hydrogen ...
NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells
(SPRINGER, 2008)
The isoforms of the Na+/H+ exchanger present in T84 human colon cells were identified by functional and molecular methods. Cell pH was measured by fluorescence microscopy using the probe BCECF. Based on the pH recovery ...
Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening
(American Physiological Society, 2011-04)
Inhibition of Na +/H + exchanger 1 (NHE1) reduces cardiac ischemia-reperfusion (I/R) injury and also cardiac hypertrophy and failure. Although the mechanisms underlying these NHE1-mediated effects suggest delay of mitochondrial ...
Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule
(AMER PHYSIOLOGICAL SOCBETHESDA, 2012)
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G. Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule. Am J ...
High glucose concentration stimulates NHE-1 activity in distal nephron cells: the role of the Mek/Erk1/2/p90RSK and p38MAPK signaling pathways
(Basel, 2014)
AIMS:
In models of diabetes, distal nephron cells contribute to glucose uptake and oxidation. How these cells contribute to the use of glucose for the regulation of H(+) extrusion remains unknown. We used Madin-Darby ...
NHE1 MODULATES INTRACELLULAR PH AND CELL PROLIFERATION IN HUMAN OVARIAN CANCER
(2017)
Ovarian cancer is a gynaecological disease with high mortality rate. Cancer cells produce large amounts of protons (H+). The Na+/H+ exchanger 1 (NHE1) is one of the main H+ transport systems and participates in intracellular ...
Mechanisms underlying the long-term regulation of NHE3 by parathyroid hormone
(AMER PHYSIOLOGICAL SOC, 2008)
The activity of the Na(+)/H(+) exchanger NHE3 is regulated by a number of factors including parathyroid hormone (PTH). In the current study, we used a renal epithelial cell line, the opossum kidney (OKP) cell, to elucidate ...