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NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells
(SPRINGER, 2008)
The isoforms of the Na+/H+ exchanger present in T84 human colon cells were identified by functional and molecular methods. Cell pH was measured by fluorescence microscopy using the probe BCECF. Based on the pH recovery ...
The regulation of NHE₁ and NHE₃ activity by angiotensin II is mediated by the activation of the angiotensin II type I receptor/phospholipase C/calcium/calmodulin pathway in distal nephron cells
(Amsterdam, 2013-12-05)
Angiotensin II (Ang II), acting via the AT1 receptor, induces an increase in intracellular calcium [Ca(2+)]i that then interacts with calmodulin (CaM). The Ca(2+)/CaM complex directly or indirectly activates sodium hydrogen ...
Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening
(American Physiological Society, 2011-04)
Inhibition of Na +/H + exchanger 1 (NHE1) reduces cardiac ischemia-reperfusion (I/R) injury and also cardiac hypertrophy and failure. Although the mechanisms underlying these NHE1-mediated effects suggest delay of mitochondrial ...
Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
(Elsevier, 2013-09)
Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 ...
Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity
(Elsevier, 2014-09)
Background: The involvement of NHE-1 hyperactivity, critical for pathological cardiac hypertrophy (CH), in physiological CH has not been elucidated yet. Stimulation of NHE-1 increases intracellular Na+ and Ca2 + favouring ...
Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule
(AMER PHYSIOLOGICAL SOCBETHESDA, 2012)
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, Bezerra CN, Dariolli R, Girardi AC, Fonteles MC, Malnic G. Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule. Am J ...
Transcriptional regulation of the Na(+)/H(+) exchanger NHE3 by chronic exposure to angiotensin II in renal epithelial cells
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Angiotensin II (Ang II) exerts an acute bimodal effect on proximal tubule NHE3: while low doses stimulate the exchanger, high doses inhibit it. In the present study, we have investigated the chronic effects of Ang II on ...