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NF-kB expression in IgA nephropathy outcome
(IOS PRESS, 2011)
Some studies have demonstrated the involvement of nuclear factor-kappa B (NF-kB) in the pathogenesis of glomerulonephritis. The aim of our study was twofold: (1) to analyze the prognostic value of NF-kB expression in primary ...
Role of NFKB2 on the early myeloid differentiation of CD34+ hematopoietic stem/progenitor cells
(ELSEVIER SCI LTD, 2010)
To better understand the early events regulating lineage-specific hematopoietic differentiation, we analyzed the transcriptional profiles of CD34+ human hematopoietic stem and progenitor cells (HSPCs) subjected to ...
Regulación de la vía de señalización NF-kB por la isoforma HE.1 del gen helios
(UniandesMaestría en Ciencias BiológicasFacultad de CienciasDepartamento de Biología, 2018)
La inflamación crónica se ha asociado con el desarrollo de gran número de enfermedades, tales como cáncer y enfermedades autoinmunes. Uno de los principales reguladores de la respuesta inmunológica es el factor de transcripción ...
In silico structural and functional characterization of the RSUME splice variants Short title: RSUME splice variants
(Public Library Science, 2013-02)
RSUME (RWD-containing SUMO Enhancer) is a small protein that increases SUMO conjugation to proteins. To date, four splice variants that codify three RSUME isoforms have been described, which differ in their C-terminal end. ...
DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND
(TAYLOR & FRANCIS INC, 2010)
In mammals, the production of melatonin by the pineal gland is mainly controlled by the suprachiasmatic nuclei (SCN), the master clock of the circadian system. We have previously shown that agents involved in inflammatory ...
Dimeric procyanidins are inhibitors of NF-κB–DNA binding
(Pergamon-Elsevier Science Ltd, 2009-11)
Given the central role of the transcription factor NF-kB in inflammation, molecules that can inhibit NFkB are being actively investigated. The present work characterize potential interactions between dimeric procyanidins ...
Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology
(Bentham Science Publishers, 2016-11)
Lung cancer (LC) remains the leading cause of cancer mortality worldwide, and non-small cell LC (NSCLC) represents 80% of all LC. Oxidative stress and inflammation, autophagy, ubiquitin-proteasome system, nuclear factor ...
Regulation of NF-kB signalling cascade by immunophilins
(Bentham Science Publishers, 2016-01)
The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative ...
shRNA Knockdown of NFKB1 expression inhibits proliferation and promotes apoptosis of renal cell carcinoma
(Bethesda: American Society for Cell Biology, 2017)