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Emerging new role of NFAT5 in inducible nitric oxide synthase in responseto hypoxia in mouse embryonic fibroblast cells
(2019)
We previously described the protective role of the nuclear factor of activated T cells 5 (NFAT5) during hypoxia. Alternatively, inducible nitric oxide synthase (iNOS) is also induced by hypoxia. Some evidence indicates ...
Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells
(2019)
We previously described the protective role of the nuclear factor of activated T cells 5 (NFAT5) during hypoxia. Alternatively. inducible nitric oxide synthase (iNOS) is also induced by hypoxia. Some evidence indicates ...
NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis
(SPRINGER, 2011)
Members of the nuclear factor of activated T cell (NFAT) family of transcription factors were originally described in T lymphocytes but later shown to be expressed in several immune and non-immune cell types. NFAT proteins ...
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney
(Niels Olsen Saraiva Caˆmara, Universidade de Sao Paulo, Brazil, 2012)
The current hypothesis postulates that NFAT5 activation in the kidney’s inner medulla is due to hypertonicity, resulting in
cell protection. Additionally, the renal medulla is hypoxic (10–18 mmHg); however there is no ...
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction
(2015)
During gestation, low oxygen environment is a major determinant of early placentation process, while persistent placental hypoxia leads to pregnancy-related complications such as preeclampsia (PE) and intrauterine growth ...
GSK-3 beta/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy
(2016)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated T-cells (NFAT) is associated with the promotion ...
Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells
(Nature Publishing Group, 2007-02)
Cyclooxygenase-2 (Cox-2), the gastrin-release peptide (GRP) and its cognate receptor (GRP-R) are overexpressed in a significant percentage of colorectal carcinomas and are associated with cell growth, invasiveness and tumor ...
Andrographolide reduces il-2 production in t-cells by interfering with nfat and mapk activation
(ELSEVIER SCIENCE BV, 2009)
The nuclear factor of activated T cells (NFAT) is a transcription factor essential for cytokine production during T-cell activation and is the target of several immunosuppressive drugs. Andrographolide is a diterpenic ...
NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis
(Springer Verlag (Germany), 2017)