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Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin
(Wiley, 2013-09)
Increased adult neurogenesis is a major neurobiological correlate of the beneficial effects of antidepressants. Indeed, selective serotonin (5-HT) re-uptake inhibitors, which increase 5-HT transmission, enhance adult ...
Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival
(Frontiers Media S.A., 2019-08)
Neurotrophic factors are relevant regulators of the neurogenic process at different levels. In particular, the brain-derived neurotrophic factor, BDNF, is highly expressed in the hippocampus (HC) of rodents and participates ...
A Sensory Neuron Subpopulation with Unique Sequential Survival Dependence on Nerve Growth Factor and Basic Fibroblast Growth Factor during Development
(Society for Neuroscience, 2001-11)
We characterized a subpopulation of dorsal root ganglion (DRG) sensory neurons that were previously identified as preferential targets of enkephalins. This group, termed P-neurons after their “pear” shape, sequentially ...
Newborn granule cells in the ageing dentate gyrus
(Wiley Blackwell Publishing, Inc, 2008-06)
The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in ...
Neurochemical, behavioral, and neurogenic validation of a hyposerotonergic animal model by voluntary oral consumption of PCPA
(American Chemical Society, 2020-02)
The inhibitor of tryptophan hydroxylase, para-chlorophenylalanine (PCPA), has been classically employed as a pharmacological tool to deplete serotonin (5-HT) in animal models and to evaluate whether this neurotransmitter ...
A cafeína exerce efeitos positivos sobre a memória tipo episódica em ratos adultos sem influenciar a sobrevivência neural no giro denteado
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em NeurocienciasNeurobiologia Celular e Molecular; Neurobiologia de Sistemas e Cognição; Neurocomputação Neuroengen, 2012-04-27)
The caffeine is a mild psychostimulant that has positive cognitive effects at low doses, while promotes detrimental effects on these processes at higher doses. The episodic-like memory can be evaluated in rodents through ...