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Sex differences in X-linked gene expression in embryonic hypothalamic neurons
(Sociedad Argentina de Investigación en Neurociencias, 2017)
Although sex hormones are usually considered the main architects of sexual dimorphisms, recent studies have demonstrated that sex chromosomes can also induce sex differences in somatic gene expression in the absence of ...
Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
(2002)
The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of the transcription of genes that encode these channels occurs during early neuronal development. ...
Developmental regulation of the expression of sodium currents in Xenopus primary neurons
(SOCIEDAD BIOLGIA CHILE, 2006)
The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, ...
Calcium microdomains and gene expression in neurons and skeletal muscle cells
(CHURCHILL LIVINGSTONE, 2006-12)
Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting ...
Expression Profile of Rat Hippocampal Neurons Treated with the Neuroprotective Compound 2,4-Dinitrophenol: Up-Regulation of cAMP Signaling Genes
(SPRINGER, 2010)
2,4-Dinitrophenol (DNP) is classically known as a mitochondrial uncoupler and, at high concentrations, is toxic to a variety of cells. However, it has recently been shown that, at subtoxic concentrations, DNP protects ...
Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes
(Oxford University Press, 2020-06)
Single-cell RNA-sequencing (scRNA-seq) of the Caenorhabditis elegans nervous system offers the unique opportunity to obtain a partial expression profile for each neuron within a known connectome. Building on recent scRNA-seq ...
Role of X-linked genes on sex differences in neurogenin 3 expression in developing hypothalamic neurons
(2016)
Our previous findings indicate that sex chromosome complement regulates the generation of sex differences in mouse hypothalamic neuronal development. Higher expression of neurogenin 3 (Ngn3) in XX neurons mediates sex ...
Reprogramação de astrócitos corticais em neurônios utilizando coquetel de pequenas moléculas
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2016-11-02)
Recently, many techniques have been described to generate neurons that could be used in cell-based therapies to neurodegenerative diseases or acute central nervous system injuries. One of such techniques is the lineage ...
Dicistronic MLV-retroviral vectors transduce neural precursors in vivoand co-express two genes in their differentiated neuronal progeny
(2005)
Abstract
Dicistronic MLV-based retroviral vectors, in which two IRESes independently initiate the translation of two proteins from a single RNA, have been shown to direct co-expression of proteins in several ...
Sex differences in gene expression of X-linked histone demethylase Kdm6a in embryonic hypothalamic neurons
(2018)
Kdm6a and Kdm5c are histone demethylases that play an important role as epigenetic regulators of gene transcription by removing the di- and tri-methylation of Lys27 or Lys4 on histone H3 (H3K27me2/me3 - H3K4me2/me3). Both ...