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The Hsp90-binding immunophilin FKBP52 fosters neurodifferentiation and neuroregeneration in murine models
(Shenyang Editorial Dept Neural Regeneration Res, 2021-02)
The term immunophilin involves a family of proteins whose signature domain shows peptidyl-prolyl-(cis/trans)-isomerase (PPIase) enzymatic activity, i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Erlejman ...
Biological actions of the hsp90-binding immunophilins FKBP51 and FKBP52
(Multidisciplinary Digital Publishing Institute, 2019-08)
Immunophilins are a family of proteins whose signature domain is the peptidylprolylisomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through ...
Immunophilins FKBP51 and FKBP52
(MDPI, 2019)
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) ...
The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development
(American Society for Biochemistry and Molecular Biology, 2020-06-26)
Differentiation of neuronal cells is crucial for the development and function of the nervous system. This process involves high rates of membrane expansion, during which the synthesis of membrane lipids must be tightly ...
Determinação da atuação dos RTKs na neuroindução e neurogênese de células-tronco adultas de tecido de cordão umbilical humano
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Introduction : The cellular and physiological changes that accompany the aging process has pronounced effects in neurodegenerative diseases. Factors that produce neurodegeneration do so through different processes that ...
Determinação da atuação dos RTKs na neuroindução e neurogênese de células-tronco adultas de tecido de cordão umbilical humano
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Introduction : The cellular and physiological changes that accompany the aging process has pronounced effects in neurodegenerative diseases. Factors that produce neurodegeneration do so through different processes that ...
Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
(Houten, 2013)
Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and differentiation. While most of P2Y receptors ...
Survival and Neuronal Differentiation of Mesenchymal Stem Cells Transplanted into the Rodent Brain Are Dependent upon Microenvironment
(MARY ANN LIEBERT INC, 2010)
Introduction: The successful integration of stem cells in adult brain has become a central issue in modern neuroscience. In this study we sought to test the hypothesis that survival and neurodifferentiation of mesenchymal ...
Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52
(Bentham Science Publishers, 2014-05)
Immunophilins comprise a family of intracellular proteins with peptidyl-prolyl-(cis/trans)-isomerase activity. These foldases are abundant, ubiquitous, and able to bind immunosuppressant drugs, from which the term immunophilin ...
Altered resting-state functional connectivity in hiPSCs-derived neuronal networks from schizophrenia patients
(Frontiers Media, 2022)
Schizophrenia (SZ) is a severe mental disorder that arises from abnormal neurodevelopment, caused by genetic and environmental factors. SZ often involves distortions in reality perception and it is widely associated with ...