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Neurogenin 3 mediates sex chromosome effects on the generation of sex differences in hypothalamic neuronal development.
(Frontiers in Cellular Neuroscience., 2014)
The organizational action of testosterone during critical periods of development is the cause of numer o ussex differences in the brain. However, sex differences in neuritogenesis have been detectedin primary neuronal ...
Interaction of sex chromosome complement, gonadal hormones and neuronal steroid synthesis on the sexual differentiation of mammalian neurons
(Taylor & Francis Ltd, 2017-10-27)
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neurites than male mouse neurons. This sex difference in neuritogenesis is determined by higher expression levels of the ...
uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis
(Wiley, 2014-05)
BACKGROUND: In the development of the central nervous system (CNS), neuronal migration and neuritogenesis are crucial processes for establishing functional neural circuits. This relies on the regulation exerted by several ...
Estudio de los efectos que la actividad de la quinasa Cdk5 ejerce sobre la actividad y localización sub-celular de la GTPasa Rac1 en células neuronales embrionarias en el contexto de la neuritogénesis
(Universidad de Chile, 2014)
Rac1 es una pequeña proteína monomérica con actividad GTPasa que fluctúa entre
una conformacion activa (unida a GTP) y una inactiva (unida a GDP). Racl-GTP se
asocia directamente a proteínas que regulan la polimerizacion ...
Neuroprotective effect of FK506 against oxidative stress
(Sociedad Argentina de Neurociencias, 2020)
Cellular prion protein binds laminin and mediates neuritogenesis
(Elsevier B.V., 2000-03-10)
Laminin (LN) plays a major role in neuronal differentiation, migration and survival. Here, we show that the cellular prion protein (PrPc) is a saturable, specific, high-affinity receptor for LN. the PrPc-LN interaction is ...
Choline Kinase alpha Expression during RA-induced Neuronal Differentiation: role of C/EBPβ
(Elsevier, 2014-04)
Neuronal differentiation is a complex process characterized by a halt in proliferation and extension of neurites from the cell body. This process is accompanied by changes in gene expression that mediate the redirection ...
Cutaneous inflammation differentially regulates the expression and function of Angiotensin-II types 1 and 2 receptors in rat primary sensory neurons
(Wiley Blackwell Publishing, Inc, 2020-03)
Neuropathic and inflammatory pain results from cellular and molecular changes in dorsal root ganglion (DRG) neurons. The type-2 receptor for Angiotensin-II (AT2R) has been involved in this type of pain. However, the ...
Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons
(Nature Research, 2020-12)
Hypothalamic neurons show sex differences in neuritogenesis, female neurons have longer axons and higher levels of the neuritogenic factor neurogenin 3 (Ngn3) than male neurons in vitro. Moreover, the effect of 17-β-estradiol ...
N-Acetyl cysteine and catechin-Derived polyphenols: A path toward multi-target compounds against alzheimer's disease
(IOS Press, 2020)
Background: Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free ...