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Antifungal Activity of Naphtoquinone From Tabebuia Serratifolia (Vahl. Nicholson)
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2009)
Effect of natural Naphtoquinones in BALB/C mice infected with Leishmania amazonensis and L. Venezuelensis
(Acta Andina, 1993)
Plumbagin (1), 3,3'-biplumbagin (2) and 8,8'-biplumbagin (3) are naphtoquinones isolated by activity-directed fractionation from a Bolivian plant, Pera benensis, employed in folk medicine as treatment of cutaneous Ieishmaniasis ...
Biomimetic in vitro oxidation of lapachol: A model to predict and analyse the in vivo phase I metabolism of bioactive compounds
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012)
The bioactive naphtoquinone lapachol was studied in vitro by a biomimetic model with Jacobsen catalyst (manganese(III) salen) and iodosylbenzene as oxidizing agent. Eleven oxidation derivatives were thus identified and two ...
A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells
(2021-06-24)
Lapachol is a well-studied natural product that has been receiving great interest due to its anticancer properties that target oxidative stress. In the present work, two novel lapachol-containing ruthenium(II) complexes ...
Antitumoral, Antileishmanial and Antimalarial Activity of Pentacyclic 1,4-Naphthoquinone Derivatives
(Sociedade Brasileira de Química, 2019)
In Silico Analysis of Sea Urchin Pigments as Potential Therapeutic Agents Against SARS-CoV-2: Main Protease (Mpro) as a Target
(American Chemical Society, 2020-07)
The SARS-CoV-2 outbreak has spread rapidly and globally generating a new coronavirus disease (COVID-19) since December 2019 that turned into a pandemic. Effective drugs are urgently needed and drug repurposing strategies ...
Sea urchin pigments as potential therapeutic agents against the spike protein of SARS-CoV-2 based on in silico analysis
(American Chemical Society, 2020-06)
Several studies have been published regarding the interaction between the spike protein of the novel coronavirus SARS-CoV-2 and ACE2 receptor in the host cells. In the presente work, we evaluated the in silico properties ...
NQO1 induction mediated by photodynamic therapy synergizes with β-Lapachone-halogenated derivative against melanoma
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018-12)
The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. NQO1 plays an important role ...