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Plataformas para acelerar el descubrimento de nanobodies contra blancos de interés biomédico y sus aplicaciones
(Udelar. FQ, 2015)
Además de los anticuerpos convencionales, los camélidos poseen anticuerpos carentes de cadena liviana en los que un único dominio forma el sitio de unión al antígeno. Este dominio, denominado Nanobody o VHH, es uno de los ...
Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT
(Nature Publishing Group, 2015-01)
The spore-forming gut bacterium Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitalized patients. The major virulence factors are two large glucosylating cytotoxins. Hypervirulent strains ...
Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom
(2020)
Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites. Although effective against systemic effects, conventional ...
Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo
(Nature Publishing Group, 2017-12)
The cell surface ecto-enzyme CD38 is a promising target antigen for the treatment of hematological malignancies, as illustrated by the recent approval of daratumumab for the treatment of multiple myeloma. Our aim was to ...
The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs
(Wiley Blackwell Publishing, Inc, 2013)
Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens
(Elsevier Science, 2019-03)
Vaccination is as one of the most beneficial biopharmaceutical interventions against pathogens due to its ability to induce adaptive immunity through targeted activation of the immune system. Each vaccine needs a tailor-made ...
Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary clostridium difficile toxin CDT
(Nature Publishing Group, 2015-01)
The spore-forming gut bacterium Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitalized patients. The major virulence factors are two large glucosylating cytotoxins. Hypervirulent strains ...
Inhibition of the myotoxicity induced by crotoxin B, from Crotalus durissus terrificus venom, by camelid nanobodies
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)