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Receptores acoplados à proteína G: implicações para a fisiologia e doenças endócrinas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2001-06-01)
The majority of polypeptide hormones and even extracellular calcium signal their target cells through G protein-coupled receptors (GPCRs). Recently, many mutations have been both identified and associated with several ...
Mutações do Gene do Receptor Sensível ao Cálcio Extracelular e Suas Doenças Associadas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2002-08-01)
The extracellular calcium-sensing receptor (CaR) is a G protein coupled receptor (GPCR) that plays a key role in the regulation of extracellular calcium homeostasis, being expressed in all tissues related to this control ...
Update on the etiology, diagnosis and therapeutic management of sexual precocity
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008)
Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious puberty (GDPP) results from the premature ...
Germline mutation analysis of Tpit in Poodle dogs with ACTH-dependent hyperadrenocorticism
(ARQUIVO BRASILEIRO MEDICINA VETERINARIA ZOOTECNIABELO HORIZONTE, 2012)
There is a high incidence of pituitary-dependent hyperadrenocorticism (PDH) in Poodle dogs, with family members being affected by the disease, suggesting a genetic involvement. Tpit is an obligate transcription factor for ...
Diabetes melito neonatal
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-03-01)
Neonatal diabetes is a rare condition characterized by hyperglycemia, requiring insulin treatment, diagnosed within the first months of life. The disorder may be either transient, resolving in infancy or early childhood ...