In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...

Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution ...

Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...

In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...

Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...

Planejamento automatizado é uma capacidade importante de se ter em agentes inteligentes. Já foi realizada uma extensa pesquisa em planejamento para um único agente, porém planejamento multiagente ainda não foi totalmente ...

Planejamento automatizado é uma capacidade importante de se ter em agentes inteligentes. Já foi realizada uma extensa pesquisa em planejamento para um único agente, porém planejamento multiagente ainda não foi totalmente ...

This paper presents the core component of a solution based on agent technology specifically adapted for the classification of SOA messages. These messages can carry out attacks that target the applications providing Web ...