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Furosemide impairs nasal mucociliary clearance in humans
(ELSEVIER SCIENCE BV, 2010)
Furosemide, a potent diuretic, affects ion and water movement across the respiratory epithelium. However, the effects of furosemide, as clinically used, on mucociliary clearance, a critical respiratory defense mechanism, ...
Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model
(Faculdade de Medicina / USP, 2011)
OBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic ...
Repeated stress reduces mucociliary clearance in animals with chronic allergic airway inflammation
(ELSEVIER SCIENCE BV, 2010)
We evaluated if repeated stress modulates mucociliary clearance and inflammatory responses in airways of guinea pigs (GP) with chronic inflammation. The GP received seven exposures of ovalbumin or saline 0.9%. After 4th ...
Effects of biomass burning on nasal mucociliary clearance and mucus properties after sugarcane harvesting
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Objective: Biofuel from sugarcane is widely produced in developing countries and is a clean and renewable alternative source of energy. However, sugarcane harvesting is mostly performed after biomass burning. The aim of ...
Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis Protocol for a randomized controlled trial
(Lippincott Williams & Wilkins, 2018-02-01)
Background: Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes. The most frequent ...
Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation
(2002)
The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly ...
Nasal mucus transportability in children with cleft palate
(ELSEVIER IRELAND LTD, 2008)
Objectives: Children with cleft palate (CP) have a high prevalence of sinusitis. Considering that nasal mucus properties play a pivotal role in the upper airway defense mechanism, the aim of the study was to evaluate nasal ...
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis
(Elsevier B.V., 2013-09-01)
Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...