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Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis
(2021-08-01)
This work proposes new methotrexate (MTX) loaded drug delivery systems (DDS) to treat rheumatoid arthritis via the intra-articular route: a poloxamer based thermosensitive hydrogel (MTX-HG), oligochitosan and hypromellose ...
Bacillus sphaericus Entomocidal Potential Determined by Polymerase Chain Reaction
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2020)
Antimetastatic effect of Celecoxib/PLGA in a TA3-MTX-R murine breast adenocarcinoma model Efecto antimetastásico de Celecoxib/PLGA en un modelo murino de adenocarcinoma mamario TA3-MTX-R
(Universidad de la Frontera, 2015)
© 2015, Universidad de la Frontera. All rights reserved.Metastasis is the propagation process of a cancerous focus to an organ other than that in which it started; usually occurring through blood or lymphatic route. The ...
Effectiveness and toxicity of first-line methotrexate chemotherapy in low-risk postmolar gestational trophoblastic neoplasia: The New England Trophoblastic Disease Center experience
(2018-01-01)
Objectives To assess the outcomes and toxicity of first-line methotrexate (MTX) chemotherapy in low-risk postmolar gestational trophoblastic neoplasia (GTN) patients receiving 8-day methotrexate or one-day methotrexate ...
Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis
OBJECTIVE: To determine if the pharmacokinetics of methotrexate (MTX) is modified by the coadministration of etodolac. METHODS: MTX (10 mg) was administered intramuscularly in the absence and presence of steady state levels ...
Differential Gene Expression Profiles May Differentiate Responder and Nonresponder Patients with Rheumatoid Arthritis for Methotrexate (MTX) Monotherapy and MTX plus Tumor Necrosis Factor Inhibitor Combined Therapy
(J RHEUMATOL PUBL COTORONTO, 2012)
Objective. We aimed to evaluate whether the differential gene expression profiles of patients with rheumatoid arthritis (RA) could distinguish responders from nonresponders to methotrexate (MTX) and, in the case of MTX ...
Efecto Antimetastásico de Celecoxib/PLGA en un Modelo Murino de Adenocarcinoma Mamario TA3-MTX-R
(Sociedad Chilena de Anatomía, 2015)
La metástasis es el proceso de propagación de un foco cancerígeno a un órgano distinto de aquel en que se inició;
ocurriendo generalmente por vía sanguínea o linfática. La localización más frecuentes de las metástasis son ...
Use of plasma exchange in methotrexate removal in a patient with osteosarcoma and acute renal insufficiency
(Wiley-Blackwell, 2003-03-01)
Acute renal failure induced by methotrexate (MTX) can be lethal because renal excretion of the drug can be delayed. Pre-existing renal impairment, abstention, or underdosage of folinic acid and inadequate hydration facilitate ...