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Maintenance of the monomeric structure of glucokinase under reacting conditions
(1978)
Glucokinase is a monomeric protein under native and denaturating conditions yet presents a sigmoidal saturation function for glucose. These peculiarities suggested the possibility that polymerization occurs under assay ...
Thiazine dyes: Evaluation of monomeric and aggregate forms
(Pergamon-Elsevier Science Ltd, 2016-09)
The aggregation phenomenon of Azure B, monobrominated Azure B, Thionine and Methylene Blue was studied by UV–Visible spectrophotometry in different media as a function of dye concentration and temperature variations. The ...
Crystal structure of an acidic platelet aggregation inhibitor and hypotensive phospholipase A(2) in the monomeric and dimeric states: insights into its oligomeric state
(Elsevier B.V., 2004-10-08)
Phospholipases A(2) belong to the superfamily of proteins which hydrolyzes the sn-2 acyl groups of membrane phospholipids to release arachidonic acid and lysophospholipids. An acidic phospholipase A(2) isolated from Bothrops ...
Exploring Folding Aspects of Monomeric Superoxide Dismutase
(2020-01-30)
Recent studies have associated the absence of bound metals (Apo protein) and mutations in Cu-Zn Human Superoxide Dismutase (SOD1) with amyotrophic lateral sclerosis (ALS) disease, suggesting mechanisms of SOD1 aggregation. ...
A PROTEOLYTIC FRAGMENT OF TRYPANOSOMA-CRUZI TRANS-SIALIDASE LACKING THE CARBOXYL-TERMINAL DOMAIN IS ACTIVE, MONOMERIC, AND GENERATES ANTIBODIES THAT INHIBIT ENZYMATIC-ACTIVITY
(Amer Soc Biochemistry Molecular Biology Inc, 1994-03-18)
trans-Sialidase isolated from trypomastigote forms of Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, is multimeric and heterogeneous in size. We show here that limited proteolysis of trans-sialidase ...
The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant
(2015)
Escherichia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer that follows a highly cooperative threestate folding mechanism N-2 <-> 2I <-> 2U. The strong coupling between dissociation and unfolding is a consequence ...
Gating charge displacement in a monomeric voltage-gated proton (Hv1) channel
(National Academy of Sciences, 2018)
© 2018 National Academy of Sciences. All Rights Reserved. The voltage-gated proton (Hv1) channel, a voltage sensor and a conductive pore contained in one structural module, plays important roles in many physiological ...
An optimized low-cost protocol for standardized production of iron-free apoferritin nanocages with high protein recovery and suitable conformation for nanotechnological applications
(Elsevier, 2018-06)
Ferritin is a globular protein that consists of 24 subunits forming a hollow nanocage structure that naturally stores iron oxyhydroxides. Elimination of iron atoms to obtain the empty protein called apoferntin is the first ...