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The oxygen-binding properties of hemocyanin from the mollusk Concholepas concholepas
(Elsevier B.V., 2017)
© 2017 Elsevier B.V. Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. ...
Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer
(2019)
Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as ...
N-Glycosylation of mollusk hemocyanins contributes to their structural stability and immunomodulatory properties in mammals
(2019)
Hemocyanins are widely used as carriers, adjuvants, and nonspecific immunostimulants in cancer because they promote Th1 immunity in mammals. Hemocyanins also interact with glycan-recognizing innate immune receptors on ...
The oxygen binding properties of hemocyanin from the mollusk Concholepas concholepas
(Elsevier, 2017)
Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences
among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we
studied ...
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals
(2019)
Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) ...
Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual
(2011)
Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immunogenicity. Therefore they are ideal non-specific immunostimulants ...
Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages
(2016)
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in cancer. However, the mechanisms by which hemocyanins ...