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Antimicrobial Peptide K0-W6-Hya1 Induces Stable Structurally Modified Lipid Domains in Anionic Membranes
(2018-02-06)
Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) ...
A highly efficient modified human serum albumin signal peptide to secrete proteins in cells derived from different mammalian species
(Academic Press Inc Elsevier Science, 2017-04)
Signal peptides (SPs) are key elements in the production of recombinant proteins; however, little information is available concerning different SP in mammalian cells other than CHO. In order to study the efficiency of ...
Ca(2+)-mediated thiolysis of peptide-resin linkage as an option for preparing protected peptide thioesters
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A mild new procedure for preparing protected peptide thioesters, based oil Ca(2+)-assisted thiolysis of peptide-Kaiser oxime resin (KOR) linkage, is described. Ac-Ile-Ser(Bzl)-Asp(OcHx)-SR (Ac: acetyl; Bzl: benzyl; cHx: ...
Shortening and modifying the 1513 MSP-1 peptide’s ?-helical region induces protection against malaria
Immunogenic and protective peptide sequences are of prime importance in the search for an anti-malarial vaccine. The MSP-1 conserved and semi-conserved sequences have been shown to contain red blood cell (RBC) membrane ...
Structural and immunological analysis of circumsporozoite protein peptides: a further step in the identification of potential components of a minimal subunit-based, chemically synthesised antimalarial vaccine
The Plasmodium falciparum circumsporozoite protein is considered a major antimalarial-vaccine target due to its involvement in sporozoite invasion of mosquito’s salivary glands and human hepatocytes. The 4383, 4388 and ...
Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants
(Springer, 2021-11)
The use of acetylcholinesterase (AChE) inhibitors, antioxidants or multitarget compounds are among the main strategies against Alzheimer’s disease (AD). Between AChE inhibitors, those targeting the peripheral anionic site ...
Elongating modified conserved peptides eliminates their immunogenicity and protective efficacy against P. falciparum malaria
Plasmodium falciparum malaria protein peptides were synthesised in the search for more effective routes for inducing a protective immune response against this deadly parasite and this information has been associated with ...