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Magneto-mechanical model of an enzyme
(Springer Verlag Berlín, 2002-12)
It has always been difficult to clearly explain to biochemistry students how enzymes work. The idea of enzymeñsubstrate stereospecificity, active site, coupled reactions, inhibitor or activator effects, mono- and bisubstrate ...
Unraveling the nature of the catalytic power of fluoroacetate dehalogenase
(Wiley, 2018)
Fluoroacetate dehalogenase is able to cleavage a carbon-fluoride bond, the strongest carbon-halogen bond in nature, in a process initiated by a S(N)2 reaction. The role of the enzyme machinery and particularly of the halogen ...
Lipase-catalyzed synthesis of substituted phenylacetamides: Hammett analysis and computational study of the enzymatic aminolysis
(Wiley VCH Verlag, 2014-10)
A series of hydroxy-, methoxy-, and nitrophenylacetamides was synthesized by enzyme catalysis. The 28 new products were obtained through a lipase-catalyzed two-step reaction in very good to excellent yield. In the case of ...
Lipase-Catalyzed Synthesis of Substituted Phenylacetamides: Hammett Analysis and Computational Study of the Enzymatic Aminolysis
(Wiley VCH Verlag, 2014-10)
A series of hydroxy-, methoxy-, and nitrophenylacetamides was synthesized by enzyme catalysis. The 28 new products were obtained through a lipase-catalyzed two-step reaction in very good to excellent yield. In the case of ...
Cooperative RNA Polymerase Molecules Behavior on a Stochastic Sequence-Dependent Model for Transcription Elongation
(2013-02-21)
The transcription process is crucial to life and the enzyme RNA polymerase (RNAP) is the major component of the transcription machinery. The development of single-molecule techniques, such as magnetic and optical tweezers, ...
Modelling thermal stability and activity of free and immobilized enzymes as a novel tool for enzyme reactor design
(Elsevier Sci LtdOxfordInglaterra, 2007)
Prediction of the fixed-bed reactor behaviour using dispersion and plug-flow models with different kinetics for immobilised enzyme
(Elsevier Science Sa, 2003-05)
The behaviour of fixed-bed reactors, which have an immobilised enzyme on the packing surface, was studied considering steady-state conditions and external mass transfer resistance in the fluid around catalyst spherical ...
Occurrence of dead core in catalytic particles containing immobilized enzymes: analysis for the Michaelis–Menten kinetics and assessment of numerical methods
(2016-11-01)
In this article, the occurrence of dead core in catalytic particles containing immobilized enzymes is analyzed for the Michaelis–Menten kinetics. An assessment of numerical methods is performed to solve the boundary value ...
The Mode of Action of Recombinant Mycobacterium tuberculosis Shikimate Kinase: Kinetics and Thermodynamics Analyses
(2013-05-06)
Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M. tuberculosis Shikimate Kinase (MtSK), shown to be essential for survival ...