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Potencial de abuso do modafinil e sensibilização cruzada com cocaína: um estudo pré-clínico
(Universidade Federal de São Paulo (UNIFESP), 2010-06-30)
Repeated or even a single exposure to all addictive drugs causes persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational ...
Caracterização experimental da sensibilização comportamental "imediata" ao modafinil em camundongos
(Universidade Federal de São Paulo (UNIFESP), 2015-02-28)
Há grande controvérsia sobre o potencial de abuso do modafinil, uma droga aprovada para o tratamento da narcolepsia, estudada como possível agente terapêutico para o tratamento da dependência por cocaína, e utilizada de ...
Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells
(Pergamon-Elsevier Science Ltd, 2018)
The wake-promoting drug Modafinil has been used for treatment of sleep disorders, such as Narcolepsy, excessive daytime sleepiness and sleep apnea, due to its stimulant action. Despite the known effect of Modafinil on brain ...
Dopamine transporter-related effects of modafinil in rhesus monkeys
(Springer, 2010-06-01)
Modafinil is currently used as a treatment for daytime sleepiness.The objectives of this study were to explore the dopamine transporter (DAT)-related effects of modafinil on behavior and in vivo neurochemistry in rhesus ...
Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice
(Elsevier B.V., 2012-08-01)
Modafinil is a non-amphetaminic psychostimulant used therapeutically for sleep and psychiatric disorders. However, some studies indicate that modafinil can have addictive properties. the present study examined whether ...
The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus
Modafinil is a psychostimulant drug used widely for the treatment of narcolepsy, which also has additional positive effects on cognition. Here, we investigate the effects of modafinil on behavioural performance and synaptic ...
Investigação do potencial uso do Modafinil como agente melhorador da memória
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2013)
Modafinil is a drug that promotes increased alertness. It was approved for the treatment of excessive daytime sleepness in narcolepsy and obstructive sleep apnea. Some studies indicate that Modafinil can improve learning, ...
Investigação do potencial uso do Modafinil como agente melhorador da memória
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2013)
Modafinil is a drug that promotes increased alertness. It was approved for the treatment of excessive daytime sleepness in narcolepsy and obstructive sleep apnea. Some studies indicate that Modafinil can improve learning, ...
Acute Regulation of the Arousal-Enhancing Drugs Caffeine and Modafinil on Class IIa HDACs In Vivo and In Vitro: Focus on HDAC7
(Springer, 2020-05)
Psychostimulant drugs, such as modafinil and caffeine, induce transcriptional alterations through the dysregulation of epigenetic mechanisms. We have previously demonstrated that acute modafinil administration is accompanied ...
The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
(Pergamon-Elsevier Science Ltd, 2019-03)
METH use causes neuroadaptations that negatively impact the prefrontal cortex (PFC) leading to addiction and associated cognitive decline in animals and humans. In contrast, modafinil enhances cognition by increasing PFC ...