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Regulatory T cell expansion resolves after effective strongyloidiasis treatment in subjects with HTLV-1 co-infection
(Elsevier, 2020)
BACKGROUND: Regulatory T-cells (Tregs) are increased in patients with HTLV-1/Strongyloides stercoralis co-infection, and they may modify otherwise protective antigen-specific cytokine production. We hypothesized that ...
Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity
(Public Library Science, 2015-12-23)
Jorge Lobo's disease (JLD) is a chronic infection that affects the skin and subcutaneous tissues. Its etiologic agent is the fungus Lacazia loboi. Lesions are classified as localized, multifocal, or disseminated, depending ...
Characterization of the immune response in human paracoccidioidomycosis
(W B Saunders Co LtdLondonInglaterra, 2013)
Reverse engineering directed gene regulatory networks from transcriptomics and proteomics data of biomining bacterial communities with approximate Bayesian computation and steady-state signalling simulations
(2020)
Abstract
Background
Network inference is an important aim of systems biology. It enables the transformation of OMICs datasets into biological knowledge. It consists of ...
Experimental tuberculosis: Designing a better model to test vaccines against tuberculosis
(CHURCHILL LIVINGSTONE, 2010)
Experimental models of infection are good tools for establishing immunological parameters that have an effect on the host-pathogen relationship and also for designing new vaccines and immune therapies. In this work, we ...
Genome-wide scan for visceral leishmaniasis in mixed-breed dogs identifies candidate genes involved in T helper cells and macrophage signaling
(Public Library Science, 2015)
We conducted a genome-wide scan for visceral leishmaniasis in mixed-breed dogs from a highly endemic area in Brazil using 149,648 single nucleotide polymorphism (SNP) markers genotyped in 20 cases and 28 controls. Using a ...
Caracterização da resposta imune tecidual em pacientes pós-transplante renal com infecção fúngica causada pelo complexo de espécies cryptococcus neoformans / cryptococcus gattii
(Universidade Federal de São Paulo (UNIFESP), 2014-09-22)
Introduction: Yeasts of the Cryptococcus neoformans / C. gattii species complex are an important cause of infection in humans and may cause symptoms of pneumonia and meningoencephalitis. Cryptococcosis is the second major ...
Balancing immunity and tolerance: genetic footprint of natural selection in the transcriptional regulatory region of HLA-G
(Nature Publishing Group, 2015-01-01)
Human leukocyte antigen-G (HLA-G) has well-recognized immunosuppressive properties modulating the activity of many immune system cells, and polymorphisms observed at the HLA-G 5'upstream regulatory region (5'URR) may ...