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High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice
(Springer, 2020-07-31)
The impairment of mitochondrial metabolism is a hallmark of aging. Mitonuclear imbalance and the mitochondrial unfolded protein response (UPRmt) are two conserved mitochondrial mechanisms that play critical roles in ensuring ...
Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPRmt in the Skeletal Muscle of Aged Mice
(Oxford Univ Press Inc, 2020-12-01)
The impairment of the mitochondrial functions is a hallmark of aging. During aging, there is a downregulation of two mechanisms strictly associated with mitochondrial integrity, including the mitonuclear imbalance (eg, ...
Regulación del acoplamiento mitocondriaretículo endoplásmico y el metabolismo mitocondrial durante el estrés proteotóxico mitocondrial
(Universidad de Chile, 2017)
La acumulación de proteínas mal plegadas dentro de las mitocondrias genera una respuesta transcripcional adaptativa, denominada UPR mitocondrial. A través de esta respuesta, las mitocondrias señalizan hacia el núcleo para ...