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Mitochondria, myocardial remodeling, and cardiovascular disease
(2012)
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
(Humana Press, 2018-12)
Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with ...
The shape of mitochondrial dysfunction in Down Syndrome
(John Wiley & Sons Inc, 2019-07)
Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied and defined as therapeutic targets in Down syndrome (DS). Though originally associated to individual genes located in supernumerary ...
The role of mitochondrial impairment in alzheimer´s disease neurodegeneration: The Tau connection
(Bentham Science Publishers, 2020)
Accumulative evidence has shown that mitochondrial dysfunction plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial impairment actively contributes to the synaptic and cognitive failure that ...
Mitochondrial Alterations in Nonalcoholic Fatty Liver Disease. Pediatric Case Description of Three Submitted Sequential Biopsies
(Medical Univ Press, 2009-06-01)
Nonalcoholic fatty liver disease (NAFLD) is a clinical-pathological syndrome that encompasses a wide spectrum of morphologic alterations, ranging from simple hepatic steatosis to a more severe stage, known as nonalcoholic ...
Adaptive downregulation of mitochondrial function in down syndrome.
(Elsevier, 2013-01-08)
Mitochondrial dysfunction and oxidative stress are common features of Down syndrome (DS). However, the underlying mechanisms are not known. We investigated the relationship between abnormal energy metabolism and oxidative ...
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
(American Physiological Society, 2014)
Insulin is a major
regulator of glucose metabolism, stimulating its mitochondrial oxidation
in skeletal muscle cells. Mitochondria are dynamic organelles that
can undergo structural remodeling in order to cope with these ...
Mitochondrial alterations and apoptosis in smooth muscle from aged rats
(Elsevier B.V., 2004-10-04)
We studied changes in mitochondrial morphology and function in the smooth muscle of rat colon. Under confocal microscopy, tissues loaded with potentiometric dye displayed rapid and spontaneous depolarization. Cyclosporin ...
Mitochondrial alterations and apoptosis in smooth muscle from aged rats
(Elsevier B.V., 2004-10-04)
We studied changes in mitochondrial morphology and function in the smooth muscle of rat colon. Under confocal microscopy, tissues loaded with potentiometric dye displayed rapid and spontaneous depolarization. Cyclosporin ...
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease
(2017)
The identification of an early biomarker to diagnose Alzheimer's disease (AD) remains a challenge. Neuropathological studies in animal and AD patients have shown that mitochondrial dysfunction is a hallmark of the development ...