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Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
(Mdpi Ag, 2012-12-01)
Nitric oxide (NO) has been implicated in several cellular processes as a signaling molecule and also as a source of reactive nitrogen species (RNS). NO is produced by three isoenzymes called nitric oxide synthases (NOS), ...
Hydrogen peroxide, nitric oxide and ATP are molecules involved in cardiac mitochondrial biogenesis in Diabetes
(Elsevier Science Inc, 2017-11)
This study, in an experimental model of type I Diabetes Mellitus in rats, deals with the mitochondrial production rates and steady-state concentrations of H2O2 and NO, and ATP levels as part of a network of signaling ...
Brain mitochondrial dysfunction in aging
(John Wiley & Sons Inc., 2008-04)
Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by ...
Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements
(Frontiers Editorial, 2014-01)
Plant mitochondria are complex organelles that carry out numerous metabolic processes related with the generation of energy for cellular functions and the synthesis and degradation of several compounds. Mitochondria are ...
Mild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis
(PUBLIC LIBRARY SCIENCE, 2011)
Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and ...
Mitochondria, myocardial remodeling, and cardiovascular disease
(2012)
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
The use of antioxidants as potential co-adjuvants to treat chronic chagas disease
(MDPI, 2021)
Chagas disease is a neglected tropical disease caused by the flagellated protozoa Trypanosome cruzi. This illness affects to almost 8-12 million people worldwide, however, is endemic to Latin American countries. It is ...
Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic fux in skeletal muscle cells
(2023)
Background: Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. ...