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Protein misfolding and disease: The case of prion disorders
(2003)
Recent findings strongly support the hypothesis that diverse human disorders, including the most common neurodegenerative diseases, arise from misfolding and aggregation of an underlying protein. Despite the good evidence ...
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
(Frontiers Media, 2016)
Function in the development of neurodegenerative diseases
(Frontiers Media S.A., 2018)
Copyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis ...
Stabilization of partially folded states in protein folding/misfolding transitions by hydrostatic pressure
(Associação Brasileira de Divulgação Científica, 2019)
Protein Misfolding and Neurodegeneration
(American Medical Association, 2008-02)
Akey molecular pathway implicated in diverse neurodegenerative diseases is the misfolding,
aggregation, and accumulation of proteins in the brain. Compelling evidence
strongly supports the hypothesis that accumulation ...
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer’s and Prion Diseases
(2010-03-31)
The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein.
Despite the diversity of clinical symptoms associated with different PMDs, many similarities ...
Targeting stress pathways to treat neurological disorders linked to protein misfoldingProtein Misfolding
(O'Doherty, C. B.Byrne, A. C. Nova Science, 2020)
Seeding of oligomers: new strategies for Alzheimer´s diagnosis and possible implications for the progression of the disease
(Universisdad de Chile, 2010)
Alzheimer's disease (AD) is a complex neurodegenerative condition which has become a
major public health problem because of its increasing prevalence, long duration and high cost
of care. It is estimated than more than ...
Protein misfolding, signaling abnormalities and altered fast axonal transport: Implications for Alzheimer and Prion diseases
(Frontiers Media S.A., 2019-07)
Histopathological studies revealed that progressive neuropathies including Alzheimer, and Prion diseases among others, include accumulations of misfolded proteins intracellularly, extracellularly, or both. Experimental ...