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An international prospective study establishing minimal clinically important differences in the EORTC QLQ-BM22 and QLQ-C30 in cancer patients with bone metastases
(Springer, 2012-12-01)
Quality of life (QOL) is frequently an endpoint in clinical trials involving patients with advanced cancer. Statistical significance of minimal differences can be achieved with sufficient sample size, yet the actual clinical ...
Misleading reporting and interpretation of results in major infertility journals
(Elsevier Science Inc, 2016-05)
Objective To evaluate the proportion of randomized controlled trials (RCTs) published in top infertility journals indexed on PubMed that reported their results with proper effect estimates and their precision estimation, ...
A practitioner’s guide to developing critical appraisal skills What is the difference between clinical and statistical significance?
(American Dental Association, 2013)
Background. It is common to find published studies in
which the authors claim to have found significant results.
However, many times these results are only statistically
significant with no meaningful impact in clinical ...
A practitioner's guide to developing critical appraisal skills What is the difference between clinical and statistical significance?
(American Dental Association, 2013-07)
Background. It is common to find published studies in which the authors claim to have found significant results. However, many times these results are only statistically significant with no meaningful impact in clinical ...
Evidence-based guidelines for interpreting change scores for the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30
(ELSEVIER SCI LTDOXFORD, 2013-08-02)
Aim: To use published literature and experts' opinion to investigate the clinical meaning and magnitude of changes in the Quality of Life (QOL) of groups of patients measured with the European Organisation for the Research ...