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Micro and nanoscale technologies in oral drug delivery
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to
administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery
could bypass the physiological ...
Size-tunable LDH-protein hybrids towards the optimization of drug nanocarriers
(Royal Society of Chemistry, 2015-02-18)
Layered double hydroxides (LDHs) are extensively investigated as drug nanocarriers due to their anion exchange properties and potential capacity to achieve enhanced cellular trafficking and targeted delivery. In this work, ...
Towards long-term colloidal stability of silica-based nanocarriers for hydrophobic molecules: beyond the Stober method
(Royal Soc ChemistryCambridgeInglaterra, 2012)
On the binding of folic acid to food proteins performing as vitamin micro/nanocarriers
(Elsevier, 2018-06)
Folic acid (FA) encapsulation in protein matrices has been reported as a suitable method for preventing FA degradation upon storage or processing as well as to improve its bioavailability. The ability of β-lactoglobulin ...
Impact of the aggregation state of amphotericin B on its biopharmaceutical properties. Design of micro- and nanocarriers for oral delivery
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE, 2016-04-08)
This thesis is part of the development and evaluation of nanomedicines potentially able to
overcome unfavorable biopharmaceutical properties of amphotericin B (AmB), a highly
effective molecule used for the treatment of ...
Synthesis of micro- and nanoparticles of alginate and chitosan for controlled release of drugs
(Elsevier, 2019)
Over the past decades, the scientific interest in nano- and microparticles has increased, because of the potential application in many fields, such as biomedical, optical, electronic, sensors, biotechnology, pollution ...
An inhalable powder formulation based on micro-and nanoparticles containing 5-fluorouracil for the treatment of metastatic melanoma
(2018-02-01)
Melanoma is the most aggressive and lethal type of skin cancer, with a poor prognosis because of the potential for metastatic spread. The aim was to develop innovative powder formulations for the treatment of metastatic ...
Synthesis of Polydopamine-Like Nanocapsules via Removal of a Sacrificial Mesoporous Silica Template with Water
(Wiley VCH Verlag, 2017-02)
Hollow polymeric polydopamine (PDA) micro-/nanocapsules have been obtained through a very simple, mild, and straightforward method that involves coating of silica mesoporous nanoparticles through an ammonia-triggered ...
Collagen-silica nanocomposites as dermal dressings preventing infection in vivo
(Elsevier Science, 2018-12)
The controlled delivery of multiple drugs from biomaterials is a timely challenge. In particular the nanocomposite approach offers a unique opportunity to combine the scaffold-forming ability and biocompatibility of hydrogels ...