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Major histocompatibility complex (MHC) class II but not MHC class I molecules are required for efficient control of Strongyloides venezuelensis infection in mice
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
P>Strongyloides stercoralis is an intestinal nematode capable of chronic, persistent infection and hyperinfection of the host; this can lead to dissemination, mainly in immunosuppressive states, in which the infection can ...
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins
(Wiley, 2016)
The evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class ...
CIITA B-cell specific promoter suppression in MHC class II-silenced cell hybrids
(Springer-Verlag, 1998)
In this study, various sets of somatic cell hybrids,
generated by the fusion of epithelial cell lines
with B-lymphoblastoid cell lines, were analyzed for the
expression of major histocompatibility complex (MHC)
class ...
MHC class I and II expression in juvenile dermatomyositis skeletal muscle
(CLINICAL & EXPER RHEUMATOLOGY, 2009)
Objective To assess MHC I and II expressions in muscle fibres of juvenile dermatomyositis (JDM) and compare with the expression in polymyositis (PM), dermatomyositis (DM) and dystrophy. Patients and methods Forty-eight JDM ...
Improved peptide-MHC class II interaction prediction through integration of eluted ligand and peptide affinity data
(Springer, 2019-05)
Major histocompatibility complex (MHC) class II antigen presentation is a key component in eliciting a CD4+ T cell response. Precise prediction of peptide-MHC (pMHC) interactions has thus become a cornerstone in defining ...
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification
(Springer, 2015-09)
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound ...
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins
(2016)
The evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class ...
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator
(Oxford University Press, 2002)
MHC class II expression defects have been evidenced in several human tumor cell lines originating from lung cancers or retinoblastoma. Accordingly, the mouse adenocarcinoma and fibrosarcoma cell lines, RAG and L(tk-), do ...
Immune complexes (IC) down-regulate the basal and interferon-γ-induced expression of MHC class II on human monocytes
(Wiley Blackwell Publishing, Inc, 2001-08)
The interaction of Fc receptors for IgG (FcγRs) on monocytes/macrophages with immune complexes (IC) triggers regulatory and effector functions. Previous studies have shown that FcγR-IC interactions inhibit the IFN-γ-induced ...
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data
(Oxford University Press, 2020-07)
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses. MHC molecules come in ...