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Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
(MDPI, 2021-11)
Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range ...
Insulin receptor membrane retention by a traceable chimeric mutant
(Biomed Central, 2013-06)
Background: The insulin receptor (IR) regulates glucose homeostasis, cell growth and differentiation. It has been hypothesized that the specific signaling characteristics of IR are in part determined by ligand-receptor ...
Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism
(Nature Publishing Group, 2017-01-27)
Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish ...
Tumor necrosis factor-astimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(Blackwell Munksgaard, 2007-12-11)
Membrane type 1-matrix metalloproteinase (MT1-
MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In
periodontal tissues, either cytokines or growth factors regulate the production of
proteolytic ...
A deep learning-based approach to model anomalous diffusion of membrane proteins: The case of the nicotinic acetylcholine receptor
(Oxford University Press, 2021-10)
We present a concatenated deep-learning multiple neural network system for the analysis of single-molecule trajectories. We apply this machine learning-based analysis to characterize the translational diffusion of the ...