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Interaction of a polyarginine peptide with membranes of different mechanical properties
(Multidisciplinary Digital Publishing Institute, 2019-10)
The membrane translocation efficiency of cell penetrating peptides (CPPs) has been largely studied, and poly-arginines have been highlighted as particularly active CPPs, especially upon negatively charged membranes. Here ...
Flunitrazepam-membrane non-specific binding and unbinding: Two pathways with different energy barriers
(Elsevier Science, 2002-02-19)
The effect of molecular packing on flunitrazepam's ability to interact with bio-membranes was studied using dipalmitoylphosphatidylcholine monomolecular layers at the air-water interface as a model membrane. Flunitrazepam ...
Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
(American Chemical Society, 2014-06)
It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine<br />adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical<br />model system to study biomembrane penetration ...
Membrane adsorption or penetration differentially modulates β-galactosidase activity against soluble substrates
(Elsevier Science, 2002-01)
We investigated if in complex environments, like those where β-galactosidase activity is usually assayed, the kinetics of hydrolysis against soluble substrates could be modulated through enzyme-surface interactions. Kinetic ...
Retained Host Descemet Membrane (Auto-DMET) During Conversion of Deep Anterior Lamellar Keratoplasty to Penetrating Keratoplasty: A Case Report
(Lippincott Williams & Wilkins, 2014-08-01)
Purpose: The aim of this study was to relate a case of deep anterior lamellar keratoplasty (DALK) converted to penetrating keratoplasty in which the host central Descemet membrane (DM) with a large perforation was left ...
Nanoparticles modified with cell penetrating peptides: Assessing adsorption on membranes containing acidic lipids
(Elsevier Science, 2021-01)
Cell-penetrating peptides (CPP) are poly-cationic molecules that facilitate the cellular uptake of nano-sized cargoes. Accumulation of the cargoes on the cell surface regulates the cargoes internalization rate and constitutes ...
Thermodynamics of cell penetrating peptides on lipid membranes: Sequence and membrane acidity regulate surface binding
(Royal Society of Chemistry, 2020-10)
Cell-penetrating peptides (CPPs) are molecules that traverse cell membranes and facilitate the cellular uptake of nano-sized cargoes. In this work we characterize the adsorption of amphipathic and purely cationic CPPs on ...
Membrane penetration and trapping of an active particle
(AMER INST PHYSICS, 2019)
The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(Elsevier Ireland, 2017-10)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...