Buscar
Mostrando ítems 1-10 de 83
Binder-free twin-screw melt granulation: An effective approach to manufacture high-dose API formulations
(Elsevier Science, 2021-09-05)
This study investigates the use of twin-screw binder-free melt granulation (BFMG) in the development of high- dose solid dose formulations for low melting point thermally stable drugs. Both ibuprofen and guaifenesin are ...
Fluidized-bed melt granulation: The effect of operating variables on process performance and granules properties
(Elsevier Science, 2015-09-08)
This paper addresses fluid-bed melt granulation (FBMG) for seeds and a binder of the same chemical nature, i.e. with an identical melting point. The purpose of this work is to study the impact of seed size, bed temperature, ...
The effect of binder concentration in fluidized-bed granulation: Transition between wet and melt granulation
(Elsevier, 2018-04)
According to the binder nature, fluidized-bed granulation (FBG) is usually classified as wet or melt granulation. In particular, the industrial urea granulation performed in fluidized beds, is often called “melt granulation” ...
Fluidized-bed melt granulation: Coating and agglomeration kinetics and growth regime prediction
(Elsevier Science, 2016-06-03)
Mass and population balance equations are used to describe the spray-on melt granulation process in a batch fluidized bed where coating and agglomeration can occur simultaneously. Two different models are considered to ...
Hot melt granulation of coarse pharmaceutical powders in a spouted bed
(ELSEVIER SCIENCE SA, 2009)
The hot melt granulation of a coarse pharmaceutical powder in a top spray spouted bed is described. The substrate was lactose-polyvinylpyrrolidone particles containing or not acetaminophen as a drug model. Polyethylene ...
Analysis of optimal control problems and plant debottlenecking for urea granulation circuits
(American Chemical Society, 2011-11)
The optimal control of a complete urea granulation circuit is studied in this work. The dynamic circuit operation is modeled by means of population, mass, and energy balances for the equipment of an industrial urea granulation ...
Coercivity extrema in melt-spun CuCo ribbons: Effects of the magnetic moment distribution
(Amer Inst PhysicsWoodburyEUA, 1999)
Physical characterization of multiparticulate systems
(Univ Sao Paulo, Conjunto Quimicas, 2017)
The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this ...