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Luminance and chromatic signals interact differently with melanopsin activation to control the pupil light response
(Association for Research in Vision and Ophthalmology, 2016-08)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin. These cells receive afferent inputs from rods and cones, which provide inputs to the postreceptoral visual pathways. It is ...
Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits
(Cell Press, 2018-08)
Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the ...
Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits
(Elsevier (Cell Press), 2018)
Abstract: Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question ...
The importance of melanopsin activation in perception, health, and lighting design
(John Wiley & Sons Inc, 2015-05)
We reviewed the role of melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) in light-dependent functions, including circadian rhythm that is important for health, pupil responses and visual ...
Assessing Rod, Cone, and Melanopsin Contributions to Human Pupil Flicker Responses
(Association for Research in Vision and Ophthalmology, 2014-02)
Purpose: To determine the relative contributions of rods, cones and melanopsin to pupil responses in humans using temporal sinusoidal stimulation for light levels spanning the low mesopic to photopic range. Methods: A ...
Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients
(Assoc Research Vision Ophthalmology Inc, 2018)
PURPOSE: Smith-Magenis syndrome (SMS) causes sleep disturbance that is related to an abnormal melatonin profile. It is not clear how the genomic disorder leads to a disturbed synchronization of the sleep/wake rhythm in SMS ...
A five-Primary photostimulator suitable for studying intrinsically photosensitive retinal ganglion cell functions in humans
(Association for Research in Vision and Ophthalmology, 2015-01)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) can respond to light directly through self-contained photopigment, melanopsin. IpRGCs also receive inputs from rods and cones. Thus, studying ipRGC functions ...
The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin
(Associação Brasileira de Divulgação Científica, 2012)
Vertebrates have a central clock and also several peripheral clocks. Light responses might result from the integration of light signals by these clocks. The dermal melanophores of Xenopus laevis have a photoreceptor molecule ...
Toward a Clinical Protocol for Assessing Rod, Cone, and Melanopsin Contributions to the Human Pupil Response
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2011)
PURPOSE. To better understand the relative contributions of rod, cone, and melanopsin to the human pupillary light reflex (PLR) and to determine the optimal conditions for assessing the health of the rod, cone, and melanopsin ...
Horizontal cells expressing melanopsin x are novel photoreceptors in the avian inner retina
(National Academy of Sciences, 2016-11)
In the vertebrate retina, three types of photoreceptors - visual photoreceptor cones and rods and the intrinsically photosensitive retinal ganglion cells (ipRGCs) - converged through evolution to detect light and regulate ...