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Establishment and characterization of an oral mucosal melanoma cell line (MEMO) derived from a longstanding primary oral melanoma
(2013)
Oral mucosal melanoma is rare. Its incidence peaks between 41 and 60 years of age; male/female ratio is 2:1. Preferred oral sites include hard palate and maxillary gingiva. Risk factors have not been clearly identified, ...
Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels
(MDPI, 2020)
Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
Interferon-β gene transfer induces a strong cytotoxic bystander effect on melanoma cells
(Elsevier France-editions Scientifiques Medicales Elsevier, 2015-05)
A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived ...
Isolamento de uma subpopulação de células de melanoma murino com características de progenitoras tumorais e análises de suas propriedades “tronculares” e tumorigênicas
(Universidade Federal de São Paulo (UNIFESP), 2011-01-26)
Melanoma is one of the most aggressive tumors and its resistance to many current therapeutic modalities is a well known fact. It is plausible to conjecture that this resistance is intimately related to the presence of a ...
Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions
(Elsevier GmbH, 2019)
Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
Evaluation of radiation-induced genotoxicity on human melanoma cells (SK-MEL-37) by flow cytometry
(Associa????o Brasileira de Energia Nuclear, 2018)
Estudio in vitro del potencial de la terapia génica con IFN-beta como tratamiento para el melanoma: Efecto bystander, inhibición de la migración celular y potenciación con bortezomibIn vitro study of the potential of interferon-beta gene therapy for treating melanoma: Bystander effect, inhibition of cell migration and enhancement with bortezomib
(2014-04-21)
El melanoma es un cáncer maligno y altamente metastásico. Siendo el interferón-alfa humano recombinante (rhIFNa) un tratamiento aprobado para el melanoma, se propone la administración del gen del IFNa/B como estrategia ...