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Transplantation of inhibitory precursor cells from medial ganglionic eminence produces distinct responses in two different models of acute seizure induction
(Academic Press Inc Elsevier Science, 2017)
Medial ganglionic eminence (MGE) is one of the sources of inhibitory interneurons during development. Following transplantation in postnatal developing brain, MGE cells can increase local inhibition suggesting a possible ...
Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility
(Cognizant Communication Corp, 2010-01-01)
Defects in GABAergic function can cause epilepsy. in the last years, cell-based therapies have attempted to correct these defects with disparate success on animal models of epilepsy. Recently, we demonstrated that medial ...
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model
(Wiley-Blackwell, 2010-01-01)
P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the ...
Grafting of GABAergic precursors rescues deficits in hippocampal inhibition
(Wiley-Blackwell, 2010-01-01)
P>gamma-Aminobutyric acid (GABA) has an important role in the mechanism of epilepsy. Cell grafts from different sources have been performed to modulate local circuits or increase GABAergic inhibition in animal models of ...
A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
(Society For Neuroscience, 2011-11-16)
GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of ...