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MeCP2 is required for activity-dependent refinement of olfactory circuits
(Academic Press Inc Elsevier Science, 2014-01)
Methyl CpG binding protein 2 (MeCP2) is a structural chromosomal protein involved in the regulation of gene expression. Alterations in the levels of MeCP2 have been related to neurodevelopmental disorders. Studies in mouse ...
Altered neuronal network and rescue in a human MECP2 duplication model
(Nature Publishing Group Specialist Journals, 2016)
Síndrome de Rett: análisis molecular del gen MECP2 en pacientes chilenas
(2019)
El síndrome de Rett (RTT) es un trastorno neurológico progresivo caracterizado por
producir una regresión del desarrollo psicomotor en niñas previamente sanas. La mayoría de los casos son causados por variantes patogénicas ...
Normal mitral cell dendritic development in the setting of Mecp2 mutation
(Pergamon-Elsevier Science Ltd, 2012-01)
Rett syndrome (RTT) is an autism spectrum disorder caused by mutation in the gene encoding methyl CpG binding protein 2 (MECP2). Evidence to date suggests that these disorders display defects in synaptic organization and ...
Mecp2 mediates experience-dependent transcriptional upregulation of ryanodine receptor type-3
(Frontiers Media SA, 2017)
Mecp2 is a DNA methylation reader that plays a critical role in experience-dependent plasticity. Increasing evidence supports a role for epigenetic modifications in activity-induced gene expression. Hence, candidate genes ...