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Envolvimento das cininas na dor do tipo fibromialgia induzida por reserpina e o efeito dos inibidores da enzima conversora de angiotensina I em camundongos
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2019-03-29)
Fibromyalgia is a chronic disease potentially disabling, characterized by widespread pain and a range of comorbidities as hypertension, besides not having specific pathophysiology or appropriate treatment. Evidence has ...
Temporomandibular disorders and cutaneous allodynia are associated in individuals with migraine
(SAGE PUBLICATIONS LTD, 2010)
The objective of this study was to estimate and contrast the occurrence of ictal and interictal cutaneous allodynia (CA) in individuals with migraine with and without temporomandibular disorders (TMD). Both TMD and CA are ...
PAR(2) and Temporomandibular Joint Inflammation in the Rat
(Sage Publications Inc, 2010-10-01)
The proteinase-activated receptor 2 (PAR(2)) is a putative therapeutic target for arthritis. We hypothesized that the early pro-inflammatory effects secondary to its activation in the temporomandibular joint (TMJ) are ...
PAR(2) and Temporomandibular Joint Inflammation in the Rat
(Sage Publications Inc, 2010-10-01)
The proteinase-activated receptor 2 (PAR(2)) is a putative therapeutic target for arthritis. We hypothesized that the early pro-inflammatory effects secondary to its activation in the temporomandibular joint (TMJ) are ...
Long-lasting ameliorating effects of the oligodeoxynucleotide IMT504 on mechanical allodynia and hindpaw edema in rats with chronic hindpaw inflammation
(Elsevier Science, 2018-02)
Purpose Previously we showed that systemic administration of IMT504 prevents or ameliorates mechanical and thermal allodynia in rats with sciatic nerve crush. Here we analyzed if IMT504 is also effective in reducing ...
Envolvimento do receptor de potencial transitório A1 (TRPA1) em um modelo de dor neuropática mantida pelo simpático em camundongos
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2012-05-26)
Some forms of neuropathic pain are maintained by sympathetic fibers, but the underlying mechanisms are poorly understood. Thus, the aim of this study was to investigate the possible involvement of the TRPA1 receptor as ...
PKCγ-positive neurons gate light tactile inputs to pain pathway through pERK1/2 neuronal network in trigeminal neuropathic pain model
(Quintessence Publishing Co. Inc., 2015)
© 2015 by Quintessence Publishing Co Inc. Aims: To explore the possible relationship between protein kinase C gamma (PKCγ) and phosphorylated forms of extracellular signal-regulated kinases 1/2 (pERK1/2) in the rat medullary ...
Rat bone marrow stromal cells and oligonucleotides in pain research
(Humana Press, 2010-02-13)
In the last years, significant progress has been made in the medical treatment of pain. However, pathological pains, such us neuropathic pain, remain refractory to the currently available analgesics. Therefore, new therapeutic ...
PAR(2) and Temporomandibular Joint Inflammation in the Rat
(SAGE PUBLICATIONS INC, 2010)
The proteinase-activated receptor 2 (PAR(2)) is a putative therapeutic target for arthritis. We hypothesized that the early pro-inflammatory effects secondary to its activation in the temporomandibular joint (TMJ) are ...
Reduced nerve injury-induced neuropathic pain in kinin B-1 receptor knock-out mice
(Soc Neuroscience, 2005-03-02)
Injury to peripheral nerves often results in a persistent neuropathic pain condition that is characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is accompanied by a local inflammatory reaction in ...