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Pro-osteoclastic in vitro effect of Polyethylene-like nanoparticles: Involvement in the pathogenesis of implant aseptic loosening
(John Wiley and Sons Inc., 2016)
Polyethylene micro-sized wear particles released from orthopaedic implants promote inflammation and osteolysis; however, less is known about the bioactivity of polyethylene nano-sized wear particles released from the last ...
Immunolocalization of CSF-1, RANKL and OPG in the enamel-related periodontium of the rat incisor and their implications for alveolar bone remodeling
(Pergamon-elsevier Science LtdOxfordInglaterra, 2009)
High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation
(Amer Soc Biochemistry Molecular Biology Inc, 2014-03-21)
Background: Connexin proteins are essential for cell differentiation, function, and survival. Results: Global deletion of Cx37 results in increased bone mass caused by reduced osteoclast maturation. Conclusion: Our findings ...
WNT16 is robustly increased by oncostatin m in mouse calvarial osteoblasts and acts as a negative feedback regulator of osteoclast formation induced by oncostatin M
(2021-01-01)
Background: Bone loss is often observed adjacent to inflammatory processes. The WNT signaling pathways have been implicated as novel regulators of both immune responses and bone metabolism. WNT16 is important for cortical ...
Uncoupling of osteoblast-osteoclast regulation in a chemical murine model of Gaucher disease
(Elsevier Science, 2013-10)
Gaucher disease (GD) is caused by mutations in the GBA gene that confer a deficient level of activity of glucocerebrosidase (GCase). This deficiency leads to accumulation of the glycolipid glucocerebroside in the lysosomes ...
In vitro osteoclastogenesis from Gaucher patients' cells correlates with bone mineral density but not with Chitotriosidase
(Elsevier Science Inc, 2017-10)
Gaucher disease (GD) is caused by mutations on the gene encoding for the lysosomal enzyme glucocerebrosidase. Type I GD (GD1) patients present anemia, hepatosplenomegaly and bone alterations. In spite of treatment, bone ...
Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (Receptor Activator of NF-κB Ligand) through activation of toll-like receptor 2 in osteoblasts
(The American Society for Biochemistry and Molecular Biology, 2015-08-14)
Periodontitis has been associated with rheumatoid arthritis. In experimental arthritis, concomitant periodontitis caused by oral infection with Porphyromonas gingivalis enhances articular bone loss. The aim of this study ...
DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption
(2017-06-01)
Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion, as well as DC-mediated immune regulation. While DC-STAMP gene expression is upregulated in the ...