Hypoxia of the placenta is integral to complications of pregnancy, including preeclampsia, intrauterine growth restriction, and small-for-gestational age babies. Hypoxia in the placenta is associated with vascular remodeling, ...

Background and Objective: Chronic maternal hypoxia impairs fetal growth and increases the incidence of intrauterine growth restriction (IUGR). To identify the mechanisms underlying these hypoxia-related effects, we evaluated ...

ABSTRACT Context: Placental hypoxia alters production of angiogenic growth factors (AGFs), thought to be causally involved in the development of the pregnancy-specific disease preeclampsia (PE). Consistent with this, ...

Although the fetal cardiovascular defence to acute hypoxia and the physiology underlying it have been established for decades, how the fetal cardiovascular system responds to chronic hypoxia has been comparatively understudied. ...

Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...

During gestation, low oxygen environment is a major determinant of early placentation process, while persistent placental hypoxia leads to pregnancy-related complications such as preeclampsia (PE) and intrauterine growth ...

ABSTRACT One causal model of preeclampsia (PE) postulates that placental hypoxia alters the production of angiogenic growth effectors (AGEs), causing an imbalance leading to maternal endothelial cell dysfunction. We ...

ABSTRACT Chronic exposure to hypoxia raises the risk of pregnancy disorders characterized by maternal vascular dysfunction and diminished fetal growth. In an effort to identify novel pathways for these hypoxiarelated ...