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Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
(NATURE PUBLISHING GROUP, 2006)
The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in ...
Experimental evidence of MAP kinase gene expression on the response of intestinal anti-inflammatory drugs
(Elsevier B. V., 2015-09-01)
The etiopathogenesis of inflammatory bowel disease (IBD) is unclear and further understanding of the mechanisms that regulate intestinal barrier integrity and function could give insight into its pathophysiology and mode ...
MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma
(Wiley-Blackwell, 2016)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues
(2018-01-01)
Oxidative stress (OS) plays a role in uterine tissue remodeling during pregnancy and parturition. While p38 MAPK is an OS-response kinase, a precise functional role is unknown. Therefore, we conducted a systematic review ...
MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation
(MDPIBasel, 2013-05-13)
Mitogen-activated protein kinase (MAPK) pathways are activated by several stimuli and transduce the signal inside cells, generating diverse responses including cell proliferation, differentiation, migration and apoptosis. ...
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
(Lippincott, Williams & Wilkins, 2017)
Extracellular-regulated kinase and p38 mitogen-activated protein kinases are involved in the antiapoptotic action of 17β-estradiol in skeletal muscle cells
(BioScientifica, 2010-08)
17β-Estradiol (E2) stimulates the mitogen-activated protein kinases (MAPKs) in various cellular types.We have shown that the hormone activates extracellular-regulated kinase (ERK) and p38 MAPK in skeletal muscle cells. ...
The role of mitogen- and stress-activated protein kinase pathways in melanoma
(Wiley, 2011-10-10)
Recent discoveries have increased our comprehension of the molecular signaling events critical for melanoma development and progression. Many oncogenes driving melanoma have been identified, and most of them exert their ...
PTH regulation of c-Jun Terminal Kinase and p38 MAPK Cascades in cells from young and aged rats
(Springer, 2007-12)
In the present study, we examined the role of Parathyroid hormone (PTH) on the c-Jun N-terminal kinase (JNK) 1/2 and p38 mitogen- activated protein kinase (MAPK) members of the MAPK family as it relates to ageing by measuring ...
Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)(2)] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38(MAPK)/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
(PORTLAND PRESS LTD, 2011)
We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N`]copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in ...