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MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6C(lo)TLR2(hi) but Not by Ly6C(hi)TLR2(hi) Monocytes during Trypanosoma cruzi Infection.
(American Society for Biochemistry and Molecular Biology, 2017)
MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6C(lo)TLR2(hi) but Not by Ly6C(hi)TLR2(hi) Monocytes during Trypanosoma cruzi Infection.
(American Society for Biochemistry and Molecular Biology, 2016)
TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus
Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor ...
Heterozygosity for the S180L Variant of MAL/TIRAP, a Gene Expressing an Adaptor Protein in the Toll-Like Receptor Pathway, Is Associated with Lower Risk of Developing Chronic Chagas Cardiomyopathy
(UNIV CHICAGO PRESS, 2009)
Background. Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. Among T. cruzi-infected individuals, only a subgroup develops severe chronic Chagas cardiomyopathy (CCC); the majority remain asymptomatic. ...
Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the toll-like receptor pathway, is associated with lower risk of developing chronic chagas cardiomyopathy
(2009)
Background. Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. Among T. cruzi–infected individuals, only a subgroup develops severe chronic Chagas cardiomyopathy (CCC); the majority remain asymptomatic. ...
Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways
(BMC, 2013)
Abstract
Background
Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas ...
RasGEF1b: localização celular de seus domínios e papel regulador negativo sobre a ativação de NF-kappaB
(Universidade Federal de Minas GeraisUFMG, 2011-07-29)
The guanine nucleotide exchange factor RasGEF1b is a protein encoded by a gene whose expression is strongly induced in response to stimuli with Toll-like receptor (TLR) agonists. RasGEF1b is found localized at the early ...