A major goal of biomedical research is the identification of molecular and cellular mechanisms that underlie memory storage. Here we report a previously unknown signaling pathway that is necessary for the conversion from ...

Purpose This study aimed to determine the role of mammalian target of rapamycin (mTORC1) activation and catabolic markers in resistance training's (RT) antiatrophy effect during cachexia-induced muscle loss. Methods Myofiber ...

mTORC2 controls glucose and lipid metabolism, but the mechanisms are unclear. Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine brown adipocytes inhibits de novo lipid synthesis, ...

The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the ...

Understanding how stored information emerges is a main question in the neurobiology of memory that is now increasingly gaining attention. However, molecular events underlying this memory stage, including involvement of ...

Recent research has provided new mechanistic insights that amino acids (AA) coordinate protein synthesis by expressing the evolutionarily conserved target of rapamycin complex 1 (mTORC1) signaling pathway genes. An 8-week ...

Alcohol abuse is a worldwide problem with concomitant medical, social and economic costs. In Brazil, epidemiological data show an increase in the abuse of illicit and licit drugs, such as ethanol and steroids. Studies ...