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Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cells
(Nature, 2019-11)
The transport of nutrients across the placenta involves trophoblast cell specific transporters modulated through the mammalian target of rapamycin (mTOR). The vasoactive intestinal peptide (VIP) has embryotrophic effects ...
Disrupción homeostática endotelial inducida por los anticuerpos antifosfolípidos : cambios en el potencial mitocondrial, activación de autofagia y mTOR como mecanismos reguladoresEndothelial Homeostatic Disruption Induced by the Antiphospholipid Antibodies : Changes in the Mitochondrial Potential, Activation of Autophagy and mTOR As Regulatory Mechanisms
(Grupo ReproducciónMedellín,Colombia, 2020)
p-mTOR, p-4EBP-1 and eIF4E expression in canine prostatic carcinoma
(2019-02-01)
The mTOR/4E-BP1/eIF4E pathway plays important roles in the neoplastic transformation process and in tumour growth. In men, the mTOR/4E-BP1/eIF4E pathway was described as altered in different tumours, including prostate ...
Avaliação da expressão gênica e protéica da via mTOR/4EBP1/eIF4E nos carcinomas prostáticos caninos
(Universidade Estadual Paulista (Unesp), 2018-03-26)
O câncer é uma doença complexa que precisa de um microambiente favorável para seu crescimento e progressão. Esse microambiente tumoral esta constituido por células neoplásicas, vasos sanguíneos, células imunes, fibroblastos ...
Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?: intersection between inflammation, mTOR pathway, autophagy and calorie restriction
(Springer, 2021-12-01)
The coronavirus disease 2019 (COVID-19) pandemic is provoking a global public health crisis. Even though the academic world is intensively pursuing new therapies, there is still no “game changer” in the management of COVID ...
Critical role of mTOR, PPARγ and PPARδ signaling in regulating early pregnancy decidual function, embryo viability and feto-placental growth
(Oxford University Press, 2018-06)
STUDY QUESTION: What are the consequences of inhibiting mTOR, the mechanistic target of rapamycin (mTOR), and the peroxisome proliferator activated receptor gamma (PPARγ) and PPARδ pathways in the early post-implantation ...
HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner
(BioMed Central, 2018)
Abstract
Background
Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is ...