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Nitric oxide and mitochondria in metabolic syndrome
(Instituto de Histología y Embriología, 2016-04-16)
Normal cardiac function is accomplished through a continuous energy supply provided by mitochondria. Heart mitochondria are the major source of reactive oxygen and nitrogen species: superoxide anion (O2-) and nitric oxide ...
Mitochondrial nitric oxide metabolism during rat heart adaptation to high altitude: effect of sildenafil, l -NAME, and l -arginine treatments
(American Physiological Society, 2009-06)
Mitochondrial nitric oxide metabolism during rat heart adaptation to high altitude: effect of sildenafil, L-NAME, and L-arginine treatments. Am J Physiol Heart Circ Physiol 296: H1741–H1747, 2009. First published April 3, ...
Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity
(Springer Verlag Berlín, 2010-10)
Rotenone and pyridaben were tested on activities and properties of rat brain mitochondria determining Ki (inhibitor concentration at half maximal inhibition) and Imax (% of inhibition at maximal inhibitor concentration). ...
Brain mitochondrial dysfunction in aging
(John Wiley & Sons Inc., 2008-04)
Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by ...
Hypoxia induces complex I inhibition and ultrastructural damage by increasing mitochondrial nitric oxide in developing CNS
(Wiley Blackwell Publishing, Inc, 2008-12)
NO-mediated toxicity contributes to neuronal damage after hypoxia; however, the molecular mechanisms involved are still a matter of controversy. Since mitochondria play a key role in signalling neuronal death, we aimed to ...
Mitochondrial Nitric Oxide Synthase:A Masterpiece of Metabolic Adaptation, Cell Growth, Transformation, and Death
(Soc Experimental Biology Medicine, 2009-09)
Mitochondria are specialized organelles that control energy metabolism and also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis or, conversely, promote cell arrest and ...
Thyroid hormones and heart mitochondrial nitric oxide under hypovolemia
(MedCrove, 2018-09)
The aim of the present work was to examine the effect of thyroid state on rat heart mitochondria function during hypovolemia. Sprague-Dawley rats treated with T3 (hyper, 20 μg/100 g body weight) or 0.02% methimazole (hypo, ...
Hydrogen peroxide, nitric oxide and ATP are molecules involved in cardiac mitochondrial biogenesis in Diabetes
(Elsevier Science Inc, 2017-11)
This study, in an experimental model of type I Diabetes Mellitus in rats, deals with the mitochondrial production rates and steady-state concentrations of H2O2 and NO, and ATP levels as part of a network of signaling ...
Metabolismo de óxido nítrico, anión superóxido y peroxinitrito en mitocondrias de corazón: Participación del complejo I y de la mtNOS en mecanismos de disfunción mitocondrial
(2016-02-29)
El corazón, para poder suplir la demanda metabólica y contráctil, depende de las concentraciones de O2 y ATP. Las mitocondrias son las organelas encargadas de producir ATP y son los sitios subcelulares más activos en cuanto ...
Complex i syndrome in myocardial stunning and the effect of adenosine
(Elsevier Science Inc, 2011-09)
Isolated rabbit hearts were exposed to ischemia (I; 15 min) and reperfusion (R; 5-30 min) in a model of stunned myocardium. I/R decreased left-ventricle O 2 consumption (46%) and malate-glutamate-supported mitochondrial ...